Pandev opened the scoring in the 14th minute when he pounced on a poor backpass from Slovakian midfielder Juraj Kucka to beat Mattia Perrin with a clinical left-foot strike. Pandev doubled Napoli’s lead barely ten minutes later when he finished off the good work of fellow forward Lorenzo Insigne.
With Duvan Zapata still short of full match fitness, Benitez replaced the Colombian striker with Higuain in the 59th minute, but the Argentinian international failed to threaten Perrin in the hosts’ net.
AC Milan, meanwhile, claimed only their second win in six games when Valter Birsa’s 46th minute goal secured a 1-0 win at home to Sampdoria.
Sampdoria, third from bottom, have yet to win this season and their fourth defeat of the campaign was even more painful as Milan signed Birsa from the visitors’ city rivals in the off season.
The win moved Massimiliano Allegri’s injury-ravaged side up to ninth place although Milan could drop again after the remainder of the weekend fixtures.