The Argentine youngster capped off what has been a remarkable debut season in Turin in Serie A by scoring his 22nd and 23rd goals of the campaign, thus moving ahead of Carlos Tevez record.
As for Giorgio Chiellini, who got the Bianconeri’s fourth, he found the net from 20 yards on his 400th appearance for the Old Lady.
Despite the Juventus Stadium being a party atmosphere, it was Sampdoria who very nearly dampened the mood after one minute but Neto made a smart stop down at his near post from Ricardo Alvarez.
However, the Blucerchiati’s decent start was nullified after just five minutes when Dybala perched himself over a free kick. He swung it in, and Evra was waiting at the back post for an unlikely headed goal.
Any memories of that early snapshot were removed when Milan Skriniar scythed down Mario Mandzukic down in the area, earning himself a red card whilst handing a penalty to Dybala that he duly converted.
Dybala almost laid on the third soon after, but the shot following his excellent mazy run was wrapped an inch or two too close to the goalkeeper.
It was an onslaught of epic proportions, but Blucerchiati stopper Alberto Brignoli and also the woodwork were sufficient to somehow keep Juventus out for 22 more minutes.
After trying numerous times, Argentine starlet Dybala was able to grab his second via a rifled effort from outside of the box.
In the second half, the first chance fell to Chiellini who couldn’t convert from a tight angle, before seconds later Hernanes sent a very tame effort into the arms of Brignoli.
Stephan Lichtsteiner drove a shot into the side netting, but then Chiellini got his goal as he lashed home from outside of the area with the goalkeeper in no mans’ land.
Eager to replicate his defensive partner, Bonucci met a corner to poke home from four yards to pile on the misery for Sampdoria.
The victory sees Juventus head into the Coppa Italia final on May 21 full of confidence, while Sampdoria end the season in disappointment following their heavy derby defeat last weekend.